The focus of the endeavours of enterprises and other organisations has shifted from the production and sales of standardised products and services to tailor-made products according to individual customers’ requirements. Flexibility, creativity and innovation have become of utmost importance. Although many authors have argued that large enterprises are unable to adapt to the required changes, such predictions have not been realised. On the contrary, large corporations have adapted to the changes, mainly by changing and developing their organisation. Thus, changes in organisational structure, organisational culture and organisational processes have led to creativity and innovation in large enterprises. In the first part of the article, we attempt to show these adaptations briefly and systematically. In the second part, we review research on this issue and its results in large Slovenian enterprises, in order to prove the hypothesis that large Slovenian enterprises have also changed their organisation to adequately develop their creativity and innovation. We also attempt to prove that creativity and innovation have resulted in improvements of efficiency and effectiveness.